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This result is stable over different protein sets.
A basis behind FBDD is "pharmacophore", by which common atom conformations in binding sites are used for designing multi-targeted drugs [6], and several pharmacophores over different protein families are now known [15].
For the comparison of gene distribution patterns over different protein similarity thresholds, six additional sets of protein families were clustered using ascending threshold (T i, where i = {35,40,45,50,55,60}) for the percent amino acid identity between protein pairs that are included in the analysis.
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Hence, for each rule we obtained the average number of contacts between pairs of substructures in matching proteins and the standard deviation indicating the stability of these contact surfaces over different proteins.
Alone for histone H3.2 over 150 different protein species were identified [27] after separation of the intact protein species.
Figure 3b shows the distribution of EpiMatrix immunogenicity scores over the different protein sets.
Over 50 different protein scaffolds have been reported such as Affibodies, DARPins, anticalins, knottins, adnectins and monobodies [33-36] [33-36]
The following five miRNAs (miR-21, miR-143-3p, miR-223a-5p, miR-664-5p miR-664-5p miR-664-5pr targetfferent provern coding genes.
In order to explore the possibility of over-representation of different protein classes among those phosphopeptides identified in our experiments, an enrichment analysis of their gene ontology (GO) terms was implemented as previously described [10].
A high identity over 70% among different protein sequences reasonably suggests that they may hold similar function [ 26].
Recent studies of protein distributions among cristae and IBM showed significant differences in concentrations of different protein species over the IM subcompartments [35], [36].
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