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Simulated Moving Bed (SMB) has advantages over batch chromatography in terms of productivity and solvent efficiency.
The excess ethanol produced by the proposed continuous configuration over batch fermenter is quantified.
Significant gains were observed on the productivity, buffer consumption and the volume of resin required for SMCC over batch chromatography.
The guideline to choose proper dilution rate is provided and the selection criterion of the proposed continuous configuration over batch fermentation is derived.
Continuous pharmaceutical manufacturing is an emerging technology that offers potential flexibility, quality, and economic advantages over batch processing, both in process development and manufacturing.
A combination of these factors and ATR-suppression gave rise to nearly 60-fold increase in volumetric productivity in fed-batch culture over batch processes.
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