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The increased ACh level, owing to the loss of ACh-hydrolysing activity may lead to over-activation of ACh receptors.
However, existing GK activators have risks of hypoglycemia caused by over-activation of GK in islet cells and dyslipidemia caused by over-activation of intrahepatic GK.
This strongly suggests that the fear is not a consequence of the experience but an integral part of it, possibly caused by over-activation of the amygdala, the part of the brain that is responsible for fear.
CB inhibition or over-activation can have important medical consequences.
These features are useful to combat relapse, mitigate over-activation, and enhance specificity.
Thus, SIRT1 possibly represses extensive DNA damage response to fine-tune HR repair process by repressing H2AX over-activation.
Therefore, CM might result from decompensation after over-activation of this region, which leads to loss of the hypertrophic response.
These preliminary findings suggest that Native Americans failed to disinhibit pain, perhaps due to over-activation of pain inhibitory mechanisms.
Overall, treatment with BI 135558 in monkeys did not result in obvious over-activation of the HPA axis.
Chronic over-activation of this system could ultimately exhaust it, thus putting Native Americans at future risk for chronic pain.
Over-activation of the renin angiotensin aldosterone system (RAAS) contributes to avid salt and water retention in heart failure.
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