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However, complications associated with rapid protein degradation and diffusion, the cost of the high doses required for efficacy, and concerns over a correlation between extremely high doses of rhBMP-2 and cancer incidence suggest that spatiotemporal delivery strategies are necessary for the efficacy, efficiency, and safety of recombinant growth factor delivery9,10,20,21,22.
Local algorithms reduce ambiguity by aggregating matching costs over a correlation window.
The Pearson correlation coefficient is used as scoring function to measure correlation between pairs of genes over subsets of conditions when seed biclusters are expanded, while maintaining similarity over a correlation threshold.
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A weakness of this study is that no outcome tool is used to quantify change over time as a correlation to time and recovery, so there are no cut offs that are specific to a Spanish population.
Our best results are highly correlated official government data, with a correlation over 0.90, providing validation of our approach.
To avoid collinearity, all variables were checked for pairwise correlation using Pearson's correlation test in R; pairs with a correlation over 0.7 were deemed highly correlated and, in the event that they were found significantly associated with in any of the investigated outcomes, only the one variable with the lowest P value was adjusted for when testing for association with the SNPs.
According to Cohen, we classified a correlation coefficient over 0.5 as a strong relation, 0.3 to 0.5 as moderate, 0.1 to 0.3 as small, and below 0.1 as no relation between constructs at all [ 37].
(For statistics nerds, it's an over -0.7 correlation, which was higher than the correlations for demographics like education, income, and those saying they are "very conservative").
Using exclusively primary human CD4+ T cells we found a correlation between over-expression of PGE2 in tumor cells and tumor-induced CD4+ T cell apoptosis.
Our results indicate a correlation of over-expression of the miR17-5p-92 cluster members with poor patient survival (p<0.009), although the p-value was not significant following a highly conservative correction for multiple comparisons.
Many previous studies have described a correlation between over-expression of LPP3 as an enzyme and down-regulation of cell signaling.
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