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At the peak of the primary immune response to LM-OVA, about 55% Smad4-sufficient Kb-ova+CD8+ splenic T cells expressed high amounts of KLRG1 and downregulated CD127, characteristics of SLEC.
Women who donate ova require information about risks, which for women considering donation for research may not be balanced by compensating benefits.
Both GEN3 and primary PDC engulfed LY and OVA with the same efficiency, but less efficiently than MoDC (about ten-fold higher tracer capture was observed with MoDC compared to PDC).
Well now those eggs will never hatch, they're barren, brittle ova of nothing.
1944 Dr John Rock and his assistant Miriam F Menkin succeed in fertilising four ova at the Free Hospital for Women, Massachusetts.
Using ovalbumin (OVA) as a model antigen, LSs formulated with OVA were orally fed to mice.
It was Ova over Ova.
Fertilized ova like soft rock!
Maybe we need to crack a few ova to make an omelet.
Following nasal administration, Ag-loaded DCs (CD11c+ MHC class II+) and B cells were observed mainly in mediastinal lymph nodes (Fig. 1), with about 9% of OVA+ DCs after 12 h, and 21% after 24 h (Fig. 1 A).
The same three to fourfold difference was observed in each case, except that the absolute level of CD8 T-cell expansion was 100-fold lower with the OVA protein (Fig. 1B) and about 4 5× lower with the OVA-8p compared with Lm-OVA (Fig. 1C; note the difference in Y axis values in A C), likely due to the much lower abundance of the epitope present when delivered outside the replicating pathogen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com