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An important aspect of TcTS acceptor site flexibility is the movement of Tyr119, which can adopt inward or outward orientations.
For simulations of apo and sialylated TcTS initiated from an outward Tyr119 orientation, as required for binding acceptor β-galactoside glycoconjugates, we find sampling of both inward and outward orientations of Tyr119.
Both inward and outward orientations of Tyr119 are found in apo TcTS crystal structures (see Methods) and are modeled as initial structures here, for both apo and sialylated TcTS simulations.
Similar(57)
Some scholars would argue that, because of this outward orientation, such orders should no longer be called monastic.
Their outward orientation, then, ultimately encouraged the pursuit of local interests rather than inculcating any sense of belonging to a larger community.
Increasing Indian outward orientation of the 1980s and early 1990s ended a period in which India was economically and politically inward looking isolating itself economically (import substitution) and politically.
This correlates well with the forced outward orientation of the limb when attempting to flex the knee and hip in the supine position.
The diversity of different morphologies is a result of surface activity of monomer units leading to formation of surface-rich structures and outward orientation of polar groups at the surface.
By focusing on what we are giving rather than on what we are receiving, we create a more outward orientation toward the world, which shifts our focus away from ourselves.
The side chain of Lys170, the closest of all other residues to the pathway for protein transfer with His64 in the outward orientation [62].
It is believed that one function of Lys170 is to maintain an environment of His64 that maximizes protein transfer and catalysis of the hydration of CO2 and dehydration of bicarbonate, by keeping it in its outward orientation [63].
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