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The additional sequence Lys303 Tyr305 folds as a protruding outward loop (Fig. 1C).
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Most of the 1045 genes predicted as PSE are cell wall anchored outward C-terminal (~40%) (≥ 50 AA long), followed by lipoproteins (~24%), outward loops (~11%) (≥ 100 AA long) and outward N-terminal (~17%) (≥ 50 AA long), whereas genes containing retention signals (PSE R) account only for ~8%.
Below the clips, in a digital workspace resembling graph paper, he built a flowchart to map the forking narrative — how her story might divide into strands that branch outward, or loop backward, or converge.
This ability to adjust the focus, to close in tight on some detail or pull back far enough to view Western art from a wide angle, makes for commentary that takes Watteau as a point of departure and ventures outward, then loops back around to him, the way his compositions lead the eye away from the center toward the edges and back again.
As has been previously noted [42], stabilizing the outward HEAT-9 loop conformation is an obvious way by which RanBP3 could increase the affinity of CRM1 for Ran.
In short, RanBP1 destabilizes the outward HEAT-9 loop conformation and favours the inward conformation, whereas the RanBP3 RBD appears poorly suited for stabilizing the inward, but compatible with the outward, conformation.
Further, in hMtb-BirA (as well as 2cgh), the side chains of the residue E123 and neighboring residues R135 & R215 are not defined beyond Cβ but they are well defined in the subunit A of dhMtb-BirA, a consequence probably of outward movement of loop L6.
Undo the knot by pulling the loops outward.
One has a loop projecting outward that's easily discerned by passing cells.
The first K+ bound with the top cap nucleotides at 1.02 ns, and the base of T18 nucleotide in the second edge-wise loop tilted outward to accommodate the hydrated K+ ion (Fig. 2A).
Composed outward from a hypnotizing loop that alternately sounds like dulled synthetic bells and oddly EQ'd hand drums (or both at once), Nik Dawson sets things moving at an obstinately plodding pace, eventually orbiting the central motif with a nasty pair of clacking and oscillating buzzes in the higher frequency range.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com