Sentence examples for outstanding potency from inspiring English sources
Especially, 8 displayed outstanding potency against L100I (EC50 = 17 nM with a 2.8-fold resistance ratio) and 18 was relatively more potent to E138K mutant (EC50 = 43 nM with a 4.7-fold resistance ratio).
Natural products have also made important contributions to cell biology due to their outstanding potency and specificity.
Their characteristics include outstanding potency to insects, low toxicity to mammals associated with rapid metabolic breakdown and, in appropriate cases, adequate stability on plant surfaces even in bright sunlight.
However, the fluoroethyl-1,2,3-triazole derivative had a calculated log D7.4 of 1.53 and revealed outstanding inhibition potencies of 0.006 0.13 nM (for MMP-2, -8, -9, and -13), so this compound was chosen for radiolabeling and further studies.
The DOT1L chemical probes EPZ004777, SGC0946, and EPZ-5676 not only exhibited high in vitro potency, outstanding selectivity, and clear MOA but also displayed robust on-target activities in cells.
While maintaining outstanding target selectivity, picomolar potency was achieved by locking the bioactive conformation of these inhibitors with a strategically positioned methyl sulfone substituent.
Comprehensive SAR was disclosed and compound 13b showed excellent potency (IC50 = 11.8 nM), outstanding hydrophilicity (A log P = 3.53), and relatively good kinase selectivity, being a promising lead for further evaluation.
He praised the lead cast's performances, writing that " ... Aditya Roy Kapur's depiction of the intense character is outstanding ... [which] clearly demonstrates his potency as an artiste of caliber and competence.
This property made it possible to design ligands that showed outstanding shape complementarity to kinase active sites and that bind with sub-nanomolar potency to the protein kinases PIM1 and GSK3beta [24,25].
Firrea carries similar potency.
