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PrEP use on a wider scale outside trial settings with more people taking PrEP, a higher risk of non-adherence, and possible changes in risk behavior due to less extensive counseling may well lead to the emergence of resistant strains.
These results demonstrate that patients can successfully self-monitor their INR outside trial settings.
The present study mirrors the use of PCT-guided antibiotic therapy in clinical practice and outside trial conditions.
Also, second look surgery is increasingly applied in patients at high risk of developing PC in- and outside trial setting.
Levels of side effect monitoring and awareness of meningococcus are very high within trials but may not be maintained outside trial settings.
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The GPS is a log unit pain outcome measure that is not a frequently used measure outside trials of HIV-SN.
We measured foraging effort and consumption during trials, as well as food consumption outside trials when food was freely available.
Second, for none of the signatures identified has the combined sensitivity and specificity reached a level that allows its implementation for clinical use outside trials.
Therapeutic regimens were divided into those administered in the context of clinical trials and those given outside trials, either because no trial was available at the time or because the patient refused to participate.
Validation of proteins such as CAIX or GLUT1 as intrinsic markers of cellular hypoxia is clearly important to facilitate the routine study of tumour hypoxia in clinical trials and ultimately to use this to direct clinical practice outside trials.
When used outside trials, however, the effectiveness of new drugs may differ, since patients included in clinical trials are younger on average, have less comorbidity, and show greater disease activity than real-life patients [ 3].
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