Exact(8)
The PfSERCA functional domains were very well conserved, with non synonymous mutations located outside the functional domains, except for the S769N mutation associated in French Guiana with elevated IC50 for artemether.
Nevertheless, the gene is highly variable, particularly in the largest exon outside the functional motif, while other regions appear to be under strong positive selection.
The control sample contains 7281 exons that do not code the proteins functional sites and are located outside the functional sites area.
Outside the functional clades, expanded MYBs are represented by dichotomous pairs of grape MYB15, 17, 35, 67 and 102 homologues, whose functions have yet to be determined.
Although in vitro and in vivo studies of MM cell lines are abundant, studies of primary MM cells are limited, often due to difficulties with maintaining primary MM outside the functional BM.
Moreover, as the GFP tag is outside the functional domains of the TR, it is not affected by any structural changes that occur upon ligand or cofactor binding, and the affinity of the antibody for the apo- or the holo-TR is probably identical.
Similar(52)
Possible orthologues between both species appear outside and inside the functional clades previously described for Arabidopsis (Additional files 4 and 5).
Think stylish on the outside, functional on the inside.
It was thus considered outside of the functional DR range for this strain.
In principle, older retrotransposons typically lie outside of the functional centromere (Wolfgruber et al. 2009; Li et al. 2013) and can be compared with the distribution of LINE and other TEs in pericentromeres of human chromosomes (Schueler et al. 2001).
The ability to separate translocation velocity from force generation in displacing a potential 'roadblock' has mechanistic implications and substantiates our belief that we are not forming a wild-type hexamer within a higher-order structure that has catalytically inactive subunits positioned outside of the functional hexamer.
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