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Evasion of CD8+ T cell responses involves mutations within and outside targeted epitopes that can result in the inability of the peptide to bind to Class I MHC, the loss of recognition of the epitope by the CD8+ T cell receptor, or interference with peptide processing [15] [19].
And last, we used TGE-MPS for CNV detection, making it impossible to map breakpoints that occur outside targeted exonic regions.
False positive may occur due to synonymous mutations, while false negative occurs due to mutations outside targeted regions or resistance caused by other mechanisms.
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CEO of Professional Science Editing for Scientists @ prosciediting.com