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Exact(2)
Outer fragments are runs of unique sites that may be evidence of past gene conversion events that originated from outside of the alignment or else from within the alignment but such that evidence of the source has been destroyed by later mutation or gene conversion (see http://www.math.wustl.edu/∼sawyer/geneconv/gconvdoc.html#AssessSig).
The mutual information on the interactions in different species within the alignment is 6.6-times higher than for the interactions among ORFs outside of the alignment [see Additional file 1 for details].
Similar(58)
Alignments that extend outside of the embedded domains into the shuffled sequence are overextended.
"The outside of the building".
Despite the high level of detection, more than 80% of the alignments fell outside the coding sequences.
This is, however, a minor error-source, since the annotations in general are several times longer than a read length, and since the depth of the alignments always decreases rapidly outside of the annotation.
In many cases, the N-termini of sporozoan proteins extend outside the alignment (data not shown).
"That's the hardest position aside from strong safety to play, because of the alignments.
eMFE of the alignments.
a "Global inner recombination" denotes recombination between ancestors of sequences in alignment; no significant support was found for recombination events involving an ancestor outside the alignment or events obscured by subsequent mutations (i.e., "Global outer fragments").
Notably, the residues identified by the BPPS procedure are highly conserved in the ErbB family (foreground alignment) and strikingly different in receptor tyrosine kinases outside of the ErbB family (background alignment) (Figure 1).
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