The investigators decided at the outset of the trial not to study artemether-lumefantrine (Coartem), despite being an excellent antimalarial, because there was no data on safety in African pregnant women.
Additionally, the same technical team conducted all fieldwork from study outset to completion.
Together, this increased annual student placement capacity at the role-emergent LTC facilities from zero at the study's outset to a total of 46 by the end of the study.
The synovial intima contains a substantial proportion of monocyte-derived macrophages (∼33%) in addition to the fibroblast-like synoviocytes (∼67%), plus a smaller proportion of vascular cells (45), so it was important at the outset to define the cells being studied.
Immediate feedback would appear to be a promising method but, at the outset of our study, studies were restricted to a few specific populations such as students and partner counselling, with the level of distress at the outset of the treatment appearing to be relatively limited (with an average ORS score of about 20).
As participants may prefer different techniques to reduce distress and improve their mood, it may be helpful, when possible (e.g., when there is direct contact with participants) to ask participants at the outset of a study to indicate what might help them should they become distressed.
14 We performed a sample size calculation at the outset of the study to check that we were likely to have data for a sufficient number of patients to produce meaningful conclusions.
Both kinds of linguists have to deal with some strange problems from the outset when studying the syllable.
All participants completed a series of tests at the outset of the study to measure short-term memory, brain processing speed, and the ability to hear and understand speech in a noisy environment.
Agreeing systems for communicating information to stakeholders at the outset of the study may help to avoid perceptions of undue interference or that the evaluator withheld important information.
Jordan rejoins that the rule does not, in fact, permit a registrant to claim at the outset of a study that they have no intent to submit a human pesticide study and then later submit that study.
