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At different time points, the suppression and reappearance of clones appeared to correlate with timing of drug therapy but the plasma cell leukaemic clone 2.2, which determined patient death, was hardly detectable at the outset, raising clear problems for predictive or prognostic biomarker strategies at diagnosis.
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Strategies worthy of investment from the outset include raising the profile of the study and ensuring clear, comprehensive, and confidential communication with potential participants [ 4].
At the outset Williams raises the question of why Burton kept the diary and for whom.
From the outset, residents raised concerns that the new water source was causing a spate of rashes and hair loss.
Thanks to decades of study on the design of apartments, prisons, cardiac intensive care units and offices, environmental psychologists now have a clear understanding of the architectural features that can achieve the latter — and few of these elements, if incorporated into a hospital design from the outset, significantly raise the cost of construction.
The design was bold, fresh and clever — but even at the outset it raised questions about its configurability and the longevity of the design.
At the outset, MoveInsure raised a small round of angel funding, but with its launch behind it, the company is setting out to raise its next round to help accelerate its growth.
The Care Bears Movie received mixed reviews from the outset; critics raised concern over its potential as a full-length advertisement for the title characters, among many other aspects.
From the outset, fire marshals said that the amount and intensity of the flames raised suspicions.
The company has also gotten regulatory clearance to test in five countries, including the U.S. Miller self-funded the company at the outset, but soon raised a pre-seed round led by Blazar Ventures (and indirectly, telecoms infrastructure standby Neustar).
The scenario is strangely muted on the question of race after raising the issue at the outset.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com