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The sensible way forward appears to be to give jurors robust instructions at the outset of a trial – not to discuss the case with others; to disregard any media reports; not to be tempted to be amateur detectives and go searching on the internet; to make their decision based only on the evidence they hear in court.
At the outset of a trial, we assume that all participants have an unobservable characteristic (or set of characteristics, known as a latent variable) that determines whether they would comply or not with the test intervention.
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At the outset of a simulation run, all intracellular metabolite levels were set to 1.0.
(I know $244 million isn't chump change, but compared to how bad things were potentially looking at the outset of the trial, the payout is a bargain).
At the outset of the trial, we did not anticipate an interaction between diet and exercise.
Even with a demographically favorable jury, at the outset of the trial, it was tough to divine how Slager's attorneys could push back against such a seemingly damning video.
Even with a demographically favourable jury, at the outset of the trial, it was tough to divine how Slager's attorneys could push back against such a seemingly damning video.
We chose a noninferiority margin (D) of −10% at the outset of this trial because we considered that this level would balance the clinical efficacy and secondary benefits.
The investigators decided at the outset of the trial not to study artemether-lumefantrine (Coartem), despite being an excellent antimalarial, because there was no data on safety in African pregnant women.
Thus, the dataset generated in the end of an RCT may be a substantially different sample size from what was predicted at the outset of the trial.
Although there was a paucity of published data available to inform the sample size estimate at the outset of the trial, the preliminary phase of the study has enabled us to make a more accurate estimation of the sample size required.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com