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So far, candidate-gene approaches have provided the most convincing evidence for the action of natural selection on particular genes, particularly when functional evidence is also available, despite the bias inherent to such approaches due to the need to make assumptions at the outset concerning the genes likely to be subject to selection.
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As we noted at the outset, concern over a health topic or outcome represents a common mechanism of many theories of persuasion and attitude change, and also with many health theories.
Since the constitution was of foreign origin, it was a source of controversy from the outset, specifically concerning the Emperor's role and Article 9. Besides, Shintô and the state were clearly separated, and Yasukuni Shrine too was made independent from the state, and has since been privately funded.
Despite claims from Balpa's chairman, Captain Mervyn Granshaw that "we were determined from the outset to concern ourselves only with the facts", the report makes some very basic mistakes which could leave readers confused.
From the outset Darwin concerned himself with the unity of humankind" (p. xvi).
From the outset he was concerned with human rights, particularly the exposure and inhibition of police and army brutality.
Yet from the outset, we were concerned about compliance.
At the outset some were concerned about the time commitment the survey would involve; "I don't think I would have bothered if it looked as though it was going to take me too long" (P8).
Stone testified that Orsborne had made plain his intentions to take the boat south from the outset, and also gave evidence concerning the changes to the ship's log.
Thus, from the outset there were significant uncertainties concerning the external validity of the data used to populate the economic model, which needs to be considered when interpreting the recommendations, particularly in younger people at lower risk of AF.
And Spencer Abraham, Mr Bush's energy secretary, has repeated for the umpteenth time that there is a serious supply crunch.At the outset such concerns seem reasonable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com