In this study, we use multi-input/single-output regulatory model to dynamically describe our gene regulatory system (i.e. multiple regulators and one target gene) that can mimic the real gene regulation in response to inflammation.
Additionally, three putative transcription factors (TR_107974, TR_110901 and TR_120365) and two G protein coupled receptors, (TR_57101 and TR_63981) were downregulated in all three mutants in light, suggesting altered signal perception as well as output on regulatory targets.
The transformation of the electric utility industry has resulted in a shift in emphasis on consumers, regulators and utilities from the traditional input-focused regulation to an output-focused regulatory framework.
Firstly, any functional genomic study focusing on a system with a strong metabolic component is well suited to metabolomics, as many of the key outputs and regulatory stages will involve a significant number of metabolites.
Furthermore, since the national regulation of the Italian energy market has been changed several times during last years, one has to take past values with particular care on the chosen period in order to avoid to treat non homogeneous numbers resulting as the output of different regulatory settings.
With respect to the genetic regulatory output, this distinction between male and female responses to IF when compared to 20% CR (negating any effect of caloric intake or body mass) was also apparent.
We hypothesized that some lncRNAs could potentially be processed to small RNA and thus could have a dual regulatory output.
By virtue of cell-specific chromatin environments, this machinery can directly integrate a diversity of regulatory output processes.
To add complexity, conditional interactions of CES with additional proteins could be decisive for the regulatory output mediated by this transcriptional regulator.
However, gene expression patterns that appear conserved between species may also be the output of divergent regulatory networks (Ludwig et al., 2005).
