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However, about 5 10% of the samples deviate from normality and include genes with significantly outlying expressions.
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Because single outlying expression values occur rather frequently and are likely to affect any analysis method, a modified version of the Nalimov outlier test (Kaiser and Gottschalk 1972) was applied to identify these potential artifacts.
The uniform component represents outlying pathway expression due to significantly high or low expression.
The grey module is a grouping of probes with outlying gene expression profiles and was not considered further.
No obvious batch effect or outlier was found for the hypegravity analysis, while the outlying general expression profile of one sample from the parabolic flight experiment was removed before test statistic (for an overview: see Table 4).> A parametric ANOVA comparing the conditions given in Table 5 was performed.
DriverNet classifies driver mutations as mutations that propagate outlying downstream differential expression in the transcriptional regulatory network [ 13].
There were also 1176 genes from some overlap data to deviated outlying data, with lower expression compared to normal condition.
Following this analysis, Feenders and colleagues found that gene expression levels in outlying striatum can vary as a function of behavior (e.g. hopping and flying [39]).
A first approach is unsupervised and relies on outlier detection to scan expression profiles for outlying values (Kadota et al., 2003, 2006).
Specifically, a jackknife procedure, applied to the signals of multiple probesets associated to the same gene, removed outlying probeset and generated a unique expression value only from highly correlated probesets.
For both the OD method and weighted variants of the outlying degree (WOD), we first define an expression distance matrix D of dimension n × m-1 containing the absolute values of the pairwise expression differences between the current sample j and the remaining samples in the cohort indexed by j' for gene i.
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