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The vast majority of studies had small sample sizes (range 36 250), with only one with a reasonable sample size n=410 (sample size calculated on the CSR meta-analysis outlined below indicates a sample of >700 is required); quality of the studies is highly varied, with concerns mostly regarding allocation sequence generation and allocation concealment, which this proposed study addresses.
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In fact, as examples outlined below indicate, timing and duration of exposure and observation in chemical carcinogenesis bioassays may determine whether the results are positive or negative.
The work is carefully performed and worthy of publication once the following revisions, indicated by the reviewers and outlined below, have been addressed.
The analyses outlined below methodically addressed these issues and indicated that the Drosophila circadian clock is remarkably sensitive to the environmental daily time cues represented in natural environmental temperature profiles.
Bearing in mind that this paper draws on selected data, the components of the study are outlined below and the sources reported on in this paper are indicated.
The eyes were collected at each time point as indicated, with western blotting, ELISA, and TUNEL staining performed as per the protocols outlined below.
These factors are outlined below:.
These requirements are outlined below.
These conditions are outlined below.
Arranged chronologically, as outlined below.
This protocol is outlined below.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com