Exact(1)
Anti-miR-mediated inhibition of several members of the miR379 410 showed that at least three of them (miR-134, -329 and -381) are necessary for dendritic outgrowth triggered by KCl in hippocampal neurons.
Similar(57)
Axonal outgrowth is triggered when a neuronal soma senses a suprathreshold activator concentration, subsequently extending an axon that follows the positive gradient of only this morphogen.
Nonetheless, in this work, we found that cylindrical plugs from the anterior of irradiated animals triggered outgrowth upon transplantation into the posterior of otherwise intact, unirradiated animals.
The first three stages of neuronal differentiation, with stage I being defined as the lamellipodia stage, stage II as outgrowth of neuritic process, and stage III as axonal outgrowth, occur very rapidly within 36 h of in vitro culture, while stage IV, during which dendritic growth is triggered, begins 2 3 days later, with their subsequent maturation (stage V) occurring beyond 1 week of culture.
Analysis of the catalog of somatic mutations in cancer genomes can lead to greater understanding of the mutational events that triggered clonal outgrowth and the exposures or DNA repair defects that were responsible for the mutations in the first place (Pleasance et al., 2010a, 2010b).
This indicates that neural marker gene expression and neurite outgrowth might be two uncoupled events triggered by different molecular mechanisms.
For example, a cylindrical plug of planarian tissue that has been flipped and inserted (with an inverted dorsoventral [DV] axis) triggers outgrowths (Okada and Sugino, 1937).
Irradiation eliminates neoblasts (Dubois, 1949), and yet irradiated DV-inverted plugs still trigger outgrowths in unirradiated hosts, suggesting that positional information might exist in differentiated planarian tissues (Kato et al., 2001).
The aqueous extract of G. neo- japonicum triggered maximal stimulation of neurite outgrowth at a lower concentration (50 μg/ml) with 14.22 ± 0.43% of neurite-bearing cells, compared to G. lucidum and G. frondosa that act at a higher concentration (75 μg/ml), with 12.61 ± 0.11% and 12.07 ± 0.46% of neurite-bearing cells, respectively.
The NCAM and L1 family of adhesion molecules are thought to trigger neurite outgrowth, axonal growth or cell migration by activation of a number of signal transduction pathways, including PLCγ-, PI3K-, Erk- and PKA-dependent pathways [7], [39].
The lesion triggered, within the first week, an ∼2-fold outgrowth of axons toward the center of the LPZ.
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