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Our results show that nanometer level surface cues are sufficient to direct nerve outgrowth through an intervening organized astrocyte cell layer.
The adult ECM restricts major reorganization of processes and axonal outgrowth through the differential expression of molecules into adulthood, and the appearance of cartilage-like structures called perineuronal nets.
The specificity of the morpholino effect was further clarified by a reversal of the decreased axonal outgrowth through co-injection of human PGRN mRNA.
It seems likely that EBNA3A (acting with EBNA3C) facilitates LCL outgrowth through the epigenetic repression of the p16INK4A gene that would otherwise cause arrest or senescence via the retinoblastoma (Rb) pathway [10], [11].
In agreement with our previous study [28], we further confirmed that L1 antibody treatment could mimic L1 L1 trans homophilic interactions to promote neurite outgrowth through a trans-interaction at cell surfaces (L1-Fc promoting neurite outgrowth is shown in Fig. S3).
AG1478 also disinhibited neurite outgrowth through effects on ErbB1.
Similar(28)
The mechanism by which GPNMB/OA promoted melanoma tumor outgrowth was through suppression of T-cell activation, which normally serves to limit tumor outgrowth [25].
Outgrowth continues through the 1.5-fold stage (460 to 490 minutes post-fertilization) until the neurite reaches the dorsal midline (Fig. 2B,C).
Our results strongly support the hypothesis that multiple inhibitors of neurite outgrowth act through the ErbB1 epidermal growth factor receptor (Koprivica et al., 2005; Schachtrup et al., 2007).
Previous studies suggested that nisin may bind covalently to a protein target during outgrowth inhibition through a Michael-type addition of a Cys of a spore protein to Dha5 of nisin.
Accordingly, S100A4-induced neurite outgrowth occurs through RAGE-independent mechanisms [ 15], and extracellular S100A4 stimulates motility and activates NF-κB in cells that do not express RAGE mRNA [ 6, 7].
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