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For instance, in vivo, Vimentin may promote neurite outgrowth in developing neurons but may play an antagonistic role in other cell types; following gene knockout, the two opposite functions are cancelled, resulting in absence of overt phenotype.
Consistent with this, Drosophila Daam (dDaam) and mouse Daam1 (mDaam1) both regulate filopodial formation and neurite outgrowth in developing neurons (Matusek et al., 2008; Salomon et al., 2008; Gonçalves-Pimentel et al., 2011).
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Brain-derived neurotrophic factor (BDNF), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing CNS, and is also known to modulate synaptic plasticity, thereby contributing to learning and memory in the mature brain.
The NEGR1 protein participates in the regulation of neurite outgrowth in the developing brain [26], [27].
Taken together, these data suggest that forced Notch signaling negatively regulates commissural axon outgrowth in the developing chick CNS.
The present study first uses an in vivo system to provide the evidence that Notch signaling regulates commissural axonal outgrowth in the developing chick CNS.
For simplicity, we only differentiated between initial neurite outgrowth in the developing embryo and dendrite maturation, which includes morphological changes during later outgrowth, branching, guidance, and pruning.
Neurotrophic factors play roles in neuronal survival, proliferation, maturation and outgrowth in the developing brain and also have neuroprotective functions after insult in the mature brain.
NEGR1 (neuronal growth regulator 1) is a growth promoter that participates in the regulation of axon outgrowth in the developing brain [ 37].
LAMB1 encodes the β1 chain of laminin, which is an important glycoprotein promoting neuronal migration and neurite outgrowth in the developing nervous system.
The two protein substrates exhibiting the strongest signals were Doublecortin (DCX) transcript variants 4 and 2. Doublecortin, which has not previously been reported as a CAMK2 subsrate, is important for neurite outgrowth in the developing brain, and acts by stabilizing microtubules [ 25].
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