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The RGD-conjugated peptide fibrils promoted neurite outgrowth in a peptide-dependent manner.
Eyles, J. et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma.
Addition of growth and differentiation factor 5 (GDF-5) further enhances neurite outgrowth in a substrate-independent manner.
Kajiwara, Y., Buxbaum, J. D. & Grice, D. E. SLITRK1 binds 14-3-3 14-3-3 14-3-3 neurite outgrowth in andhosphoregulatesdepeneuriteanner.
Finally, depletion of TRM cells triggered tumour outgrowth in a proportion (~20%) of mice with occult melanomas, demonstrating that TRM cells can actively suppress cancer progression.
TRM depletion triggered melanoma outgrowth in a proportion of previously tumour-free mice (5 out of 29), whereas no skin tumours developed in control mice (0 of 26) (Fig. 4h).
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However, the effects of Notch signaling on axon outgrowth in an in vivo condition remain largely unknown.
Inhibition of RhoA, or its downstream effector ROCK, is able to restore outgrowth in an inhibitory environment provided by myelin or myelin associated inhibitors [32], [33].
To our knowledge, this study for the first time demonstrated that amygdalin could effectively induce neurite outgrowth in an in vitro cell model of neuronal differentiation.
Silencing of Nrn1 using siRNA abolished NGF-mediated neurite outgrowth in an experimental diabetic neuropathy model, demonstrating the crucial effect of Nrn1 in regeneration.
Furthermore, glycation of VN significantly decreased VEGF-induced migration of HUVECs in vitro and vessel outgrowth in an ex vivo angiogenesis model.
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