This result implies that most of the type I survivors given sufficient outgrowth are eventually sensitive to bleomycin.
Despite this inhibition, ductal development ultimately catches up, and complete ductal outgrowth was eventually obtained in adult mice [ 4], which is consistent with a previous report [ 18].
The CDβ cell line is unique in that transplantation of cells into the epithelium-free fat pads of syngeneic female mice generates mammary outgrowths that eventually progress to tumors over time in vivo.
Scaffolds provide a temporary structure necessary for Schwann cell migration and axon outgrowth and are eventually replaced with host cells and extracellular matrix [ 20].
This observation fully agrees with the observation that SynI KO neurons display an early delay in axon outgrowth that is eventually caught up at later developmental stages, resulting in a normal synapse density (37).
A series of sequential cellular events happen during cortical development, including neural progenitor proliferation, cell fate specification, neuronal migration, neurite outgrowth and pathfinding, and eventually the formation and plastic modulation of synaptic connections [ 2].
Though acquired early, the ability to tolerate the loss of anchorage remains critical for the survival of cancer cells throughout the course of disease progression, encompassing stages such as invasion of the underlying stroma, extravasation into blood vessels, survival in the bloodstream, and, eventually, metastatic outgrowth at a distant site with a distinct matrix composition.
The observed order of events with immediate adaptation of signaling pathways over transcriptional reprogramming and eventually presumed outgrowth of genetically resistant clones suggests that there may be a finite number of escape pathways, and inhibitors to target them may already be available.
In all other cultures epithelial foci remained stationary and cultures were eventually dominated by fibroblastic outgrowth.
During anti-cancer therapy, the initial regression of the tumor eventually leads to the outgrowth of drug-resistant cells.
