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As local vasodilation increases, Pcc decreases toward outflow pressure (Fig. 1).
They model it as a collapsible tube traversing a chamber with the inflow pressure, Pmc, greater than chamber pressure, Pab, which in turn is greater than the outflow pressure, Pivc.
Outflow pressure is not uniform across organs either.
Organ perfusion pressure is the difference between the inflow pressure and outflow pressure.
As local vasodilation increases, Pcc decreases toward outflow pressure (Fig. 1).
Guyton et al. [ 23] demonstrated that RAP represents the outflow pressure (backpressure) for venous return.
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Inflow and outflow pressures differ across vascular beds and can be altered by various diseases (Table 1).
A closed control valve decouples the in- and outflow pressures and prohibits any gas flow through (a= (u, v in A_{text {cv}}).
Regrettably, there is not one threshold MAP because each organ system has a different inflow and outflow pressures and internal control systems linked to their individual physiologic roles [19].
Inflow and outflow pressures were controlled and measured by a pressure servo-control system (Living Systems Instrumentation, Burlington, VE, USA).
Inflow and outflow pressures differ across vascular beds and can be altered by various diseases (Table 1).
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