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Because these patients had generally worse baseline HAD values than group averages, the use of simple mean imputation may thus have affected outcomes slightly in favor of conventional treatment; however, sensitivity analyses showed no such effects.
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This change in outcome slightly attenuated the results, but they were not substantially different from the cancer-specific MRRs.
Disproportionate dose reduction of Dexamethasone (39% on the DA arm and 30% on the DAiS arm, P=0.12) might affect the study outcome slightly.
This means that they fail to validate when applied to independent data or may demonstrate only nominally significant predictive value (that is, they may predict outcome slightly better than chance).
EQ-5D scores at baseline, 6 and 12 month are summarised in table 3. Hospital participants EQ-5D outcomes improve slightly (+0.043) over the 12-month follow-up, whereas community participants EQ-5D outcomes decline slightly (−0.015) over same period.
EQ-5D and EQ-VAS outcomes showed slightly different patterns.
These outcomes differed slightly but not significantly by practice location.
The association between FPG and CVD outcomes was slightly attenuated after adjustment for baseline A1C.
Hence, the ICC for binary outcomes are slightly overestimated with respect to those for the continuous outcomes.
Evidence on clinical outcomes was slightly more distinct in studies with patients on maintenance therapy than in treatment-naïve patients.
Conclusions On average, single centre clinical trials with continuous outcomes showed slightly larger intervention effects than did multicentre trials.
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