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This might include differences in the participants, interventions, comparison groups, outcomes, settings or time periods across the included studies.
We extend the univariate NMA model defined above to the multiple outcomes settings in order to account for correlations between intervention effects on different outcomes.
This area of discussion focused on potential variants or extensions of existing PtDAs, and expansion of research on PtDAs to additional types of outcomes, settings, and populations.
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The standard NMA model is extended to multiple outcome settings in two stages.
This will require extending Saramago et al.'s[ 54] NMA model with aggregate and individual participant level data from single outcome to multiple outcome settings.
Approaches to extend NMA methodology to multiple outcome settings have been proposed in the literature [ 13, 25- 27], initially focusing on mutually exclusive competing risk outcomes [ 13] or a single outcome measured at multiple time points [ 26, 28].
As for the studies likely to have multiple reports, we selected the most recent publication after assessing their independency focusing on the patients' background, intervention details, outcome settings and the results.
Common data elements (CDE) represent an important tool for understanding and classifying health outcomes across settings.
Adaptive policies are able to navigate toward successful outcomes in settings that cannot be anticipated in advance.
Methods: A single case study approach explored a 'Silk Road' user's motives for online drug purchasing, experiences of accessing and using the website, drug information sourcing, decision making and purchasing, outcomes and settings for use, and perspectives around security.
Administrators and planners would be able to compare caseloads and outcomes across settings.
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