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Because neurocognition alone could account for only 20 60% of the variance in functional outcomes [ 7], social cognition, which is a common correlate of both constructs [ 6], has been speculated to be a potential candidate to explain the neurocognition-functional outcomes relation [ 9, 22].
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Several reasons might explain the lack of a volume-outcome relation in this study.
Third, it simplifies the analysis of changes in the exposure-outcome relation.
One study investigated the volume-outcome relation in medical ICU patients [ 26].
This will also need to be combined with research exploring the volume-outcome relation for outcomes other than mortality.
To be more precise, the approach proposed by Lange et al. [ 17] requires that the considered variables are sufficient for controlling the confounding of 1) the exposure-outcome relation, 2) the exposure-mediator relation, and 3) the mediator-outcome relation.
22 23 24 Two of these studies showed a volume-outcome relation, but the third study failed to do so.
Three studies, to date, have looked at the volume-outcome relation in all mechanically ventilated admissions admitted to a critical care unit.
Additional adjustment for dyslipidaemia, history of vascular disease, blood pressure and the metabolic syndrome did not affect the determinant-outcome relation (data not shown).
The variation was evident across NHS trusts that had low, medium, and high levels of activity, and we found no evidence of a volume-outcome relation.
The median Institute of Medicine quality score 7 for previous studies appraising the volume-outcome relation for cystectomy was modest, at 8.5 (range 8-11).
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