There are then two subsequent outcome possibilities with active EMT: severe and even complete organ fibrosis (Type II EMT), development of a pre-malignant stroma when associated with angiogenesis (Type III EMT) [1],[1]-[1]].
Presenting these different outcome possibilities in natural frequencies is not yet very common, but helpful (Hoffrage et al, 2000).
The scheme comprises five outcome possibilities of adjuvant therapy, ranging from patients experiencing full benefit without any harm to patients experiencing full harm, that is death from adjuvant therapy (Table 1).
The scheme comprises five outcome possibilities of adjuvant therapy: patients who benefit from adjuvant therapy (some at the cost of complications) vs those who neither benefit nor contract complications, those who do not benefit but contract severe complications, or those who die.
In complex situations in which there are multiple stimuli and outcome possibilities and when the precise spatial and temporal structure of the environment is unknown, it may not be possible to rely on a system that requires contingent predictions to drive learning ("credit assignment" problem).
The risk of bias in included studies will be assessed using the Cochrane Collaboration's risk of bias tool including sequence generation, allocation concealment, blinding, completeness of outcome data, possibility of selective outcome reporting and other potential threats to validity.
These various aspects of networking provide additional support for IHPs through information exchange, learning possibilities, joint activities (pooling funds), scaling up outcomes and possibilities of additional funding.
Randomness only requires two distinguishable possible outcomes and the possibility of production of arbitrary sequences of such outcomes.
The clinical validity (predictive value of the test results) and the clinical utility (actionable outcomes and possibilities for prevention) of PGT is likely to increase in the coming decade.
Efforts to understand family circumstances and life events represent an important frontier in the study of outcomes and possibilities.
