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The outcomes of developmental plasticity affect post-developmental health [ 5, 6].
Because of uncertainty regarding interpretation of results from different animal models, human studies remain crucial, and prospective studies must incorporate delayed adverse outcomes of developmental exposures.
Several studies have focused on predicting individual pathways from risk antecedents, but knowledge on the range of health and behavior outcomes of developmental trajectories is still limited to a few studies.
To fill the information gap between exposures to EDCs and the outcomes of developmental failure, an experimental model that enables us to investigate the early developmental stages is essential.
Our results are also limited by the fact that we examined only males, whereas there are numerous studies showing significant sex differences in the outcomes of developmental exposure to organophosphates (Aldridge et al. 2004, 2005a, 2005b; Dam et al. 2000; Levin et al. 2001; Ricceri et al. 2006; Slotkin 2005; Slotkin et al. 2001, 2002; Slotkin and Seidler 2007).
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The outcome of developmental processes depends both on the genotype and on the temporal sequence of environments in which the organism develops.
Co-citation with metabolic diseases points out that the transcriptional response in YD embryos likely associates to the disease outcome of developmental nutrient restrictions.
Several in vitro and short-term tests appear promising as screens to predict the outcome of developmental toxicity studies in mammals.
This study sought to further understand how environmental conditions influence the outcomes of early developmental insults.
The differences documented in [33], [34] could reflect differential outcomes of early developmental events [21], [35].
Owing to the number of primary tests performed, correction for multiple testing was administered using Bonferroni; alpha was set at p = 0.003 (0.05/19) for 19 tests performed (11 tests of clinical outcomes, 6 tests of cognitive outcomes and 2 tests of developmental outcomes).
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