Peel Hunt cut from hold to sell, saying: We expect a loss of £7m-8m in the first half and a full year outcome in the range of a small loss to a small operating profit, compared to a previous expectation of £16.5m profit.
Sample size estimates for potential decreases in the composite maternal, fetal, and neonatal outcomes with 90% power and alpha at 0.05 for rates of the composite outcome in the range of 70 to 90 events per 1000 deliveries, target reductions of 20%to25%5%, an intra-cluster correlation (ICC) of 0.005 (a rate that is consistent with historic Global Network mortality rates).
The prevalence's of the exposure variables ranged between 20 and 50% and the prevalence of the main outcome was in the range of 15 to 20%.
Six months later, most outcomes showed effect sizes that fell in the range of moderate effects (0.4 to 0.8), indicating lasting and clinically relevant improvements (Fig. 1).
The evidence addressing each outcome comprises a relatively small number of poor quality studies, and there are large gaps in the range of outcomes evaluated, particularly with respect to health outcomes.
For the purposes of an exploratory analysis of this sort it was calculated that recruiting 32 participants in each site would enable meaningful change in the range of outcomes, a within site medium effect size = 0.49, to be detected with 80% power at a 5% significance level.
Among the predictors and the outcome variable, data were missing in the range of 0 to 19%.
The great sensitivity of the cost-effectiveness ratio to outcome reflects the range of uncertainty in study outcomes themselves, particularly for the number needed to treat to achieve the A1C goal.
The strengths of our study lie in the range of outcomes and covariate, and the attention to time trends in RTF.
To determine whether uncertainties were sufficiently represented for robust decisionmaking, we analysed the range and diversity of the considered scenarios using the following indicators: the number of scenarios, the variety in the range of outcomes encompassed, the variety in alternatives, and the temporal and dynamic nature of the scenarios.
