Analysis of clinical outcome was performed in a total of 557 consecutive breast cancer patients operated from January 1981 to December 1999, because their clinicopathological and survival data were available for this study.
Twenty two randomised controlled trials reported effects of vitamin D supplementation in isolation on mortality outcomes, including a total of 30 716 participants in the supplement and control groups combined (table; eTable 3).
For the remaining 22 protocols where we could not deduce clearly which outcome was the primary outcome, a total of 132 outcomes were specified in the protocols (median of five, range 1-21).
The four studies included in this analysis reported outcomes on a total of 591 patients who underwent talc pleurodesis for palliation of malignant pleural effusion (Table 2).
Ignoring the global tests and proceeding with haplotype-specific analyses for each of the six outcomes would have resulted in a total of 198 tests of association.
In 2002, two randomized clinical trials showed improved neurological outcome [ 11, 12] in a total of 350 comatose adults resuscitated from OHCA who were cooled to 32-34 °C for 12-24 hourshortlyly after recovery of spontaneous circulation.
> -wrap-foot> In the main analysis, the primary outcome of herpes zoster occurred in a total of 19 143 individuals, with a higher rate among patients receiving a statin relative to nonusers of these drugs (13.25 vs 11.71 per 1000 person-years, respectively; hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.10 1.17; Figure 1).
The 383 indicators identified from all the selected sources, including the two databases, focused largely on process and outcomes in maternity care (a total of 297 indicators); structure indicators were least represented (Table 2).
Families in both groups will take part in a total of three outcome assessment sessions: (T2) immediately after the intervention (6 months after baseline), (T3) nine months after baseline, and (T4) fifteen months after baseline.
