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Despite the lack of evidence, NIPPV is still often used in these conditions [2], while outcomes data such as mortality, rate of intubation, and other complications following the use of NIPPV for the treatment of respiratory failure are concerning [2,14-23].
Studying this demographic of patients, however, is in itself challenging due to the rarity of diagnostic specimen collections with outcomes data such as metastasis and PCSM.
Moreover, there have been a range of cross-jurisdictional barriers to linking dispensing data (under the custodianship of the Commonwealth) and outcomes data such as hospitalisations (under the custodianship of individual states and territories).
Despite the lack of evidence, NIPPV is still often used in these conditions [ 2], while outcomes data such as mortality, rate of intubation, and other complications following the use of NIPPV for the treatment of respiratory failure are concerning [ 2, 14- 23].
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Outcome data, such as length of PICU stay, time to correction of DKA, and length of need for insulin drip, were not collected.
Outcome data such as recurrence, hospitalization, and death are also captured.
In addition, we obtained healthcare outcome data, such as the number of relevant medical cases in North America, Western Europe, and Australia.
The cross-sectional, nonexperimental design is an important limitation of this study as well as the lack of objective outcome data such as GHb.
As all databases include outcome data, such as morbidity and mortality, they can also be used for studies of paediatric drug safety.
Ontario possesses a comprehensive collection of linked health administrative databases containing drug, health services, socioeconomic and patients' health outcome data such as ED visits, hospitalisations and deaths.
Another disadvantage, from the regulators' point of view, is the lack of "hard" outcome data such as Quality Adjusted Life Years ("QALYs"), particularly at initial evaluation of an innovative product.
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