For item to outcome correlations, Spearman rank correlations were used.
Item to outcome correlations were significant for all 11 items.
AS performed the TMA staining for Src/Ezrin, image analysis, clinical outcome correlations, and VEGF-A/-C western blots.
Third, insulin sensitivity is only a surrogate outcome; correlations with clinical outcomes such as incident type 2 diabetes or clinical complications related to insulin sensitivity were not assessed.
The two suicide-related items had the weakest item to outcome correlations at 0.270 and 0.248, though these were still statistically significant.
For example, van 't Veer and colleagues [ 2] merely reported average outcome correlations for 232 genes of their classifier and not the original raw data.
It showed excellent internal consistencies, with.79 ≤ α ≤ .89 and good retest-reliabilities, with.69 ≤ r ≤ .92, and acceptable construct validity, with scale-outcome correlations between.27 ≤ r ≤ .81.81
However, in clinical outcome correlations only the presence of a duplication of rearranged ERG together with interstitial deletion of genomic sequences between the tandemly located TMPRSS2 and ERG sequences was correlated with worse cancer-specific death (Attard et al, 2008).
For this reason we have excluded outcome correlations with aromatase status in "on treatment" samples because we have not validated relationships between aromatase activity and expression in the presence of an endocrine agent.
Gene expression signal was used as continuous variable, and co-efficiency was applied to determine if gene expression per se was a direct (overexpression was associated with poor outcome) or inverse (overexpression was correlated with good outcome) correlation.
