If anemia is a mediator and not just a marker of poor outcomes, correcting anemia could become an important and novel therapeutic target to improve long-term outcomes in such patients.
As stated before, Rd and RILM are model outcomes corrected for losses in eye media.
In this repeated measures regression analysis, differences between groups are calculated based on the study outcomes, corrected for baseline values, to estimate true values in the random population.
If anaemia is a mediator and not just a marker of poor outcomes, correcting anaemia could become an important and novel therapeutic target to improve long-term outcomes in such patients.
Because of repeated measurements for all patients, we used linear mixed model analyses to assess differences within and between groups for all continuous outcomes, correcting for baseline scores, age, sex, proportion of patients with MRC score above 2, and clustering of patients per general practice.
In contrast, Rd (and RILM, not shown) is a model outcome corrected for losses in the eye media, including the eye lens.
This implicates that the unique contribution of these factors to stroke outcome, corrected for association with other factors, still has to be determined in order to be of value for clinical prediction in daily practice.
To check for associations with outcomes we constructed logistic regression models for hospital death and favorable long-term outcome where outcomes were corrected for confounders, with backward exclusion of non-significant (P > 0.1) parameters.
For each frequency band, we determined whether amplitude changed over the course of the nose poke or differed according to behavioral outcome (correct or incorrect).
