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However, conclusions about long-term efficacy must be tentative, because a possible bias to under reporting of poor outcomes cannot be excluded, without complete follow-up data.
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"With deeply intertwined fiscal and financial problems, failure to undertake decisive action could rapidly spread the tensions to the core of the euro area and result in large global spillovers … a disorderly outcome cannot be excluded".
As discussed above, one fatal outcome was seen in the HBOT group during the treatment period, and a relation between HBOT and this fatal outcome cannot be excluded.
Albeit the differences were not significant when separately considered, the cumulative influence of these clinical features on patients' outcome cannot be excluded.
Our study is limited to women only and a potential bias of the menstrual cycle on our outcome cannot be excluded.
Although results were robust to the different definitions of hypertension, and we selected the last BP measurement available to minimize the "white-coat effect," a residual misclassification of the outcome cannot be excluded.
A possible detrimental effect cannot be excluded.
However, an order effect cannot be excluded.
Although the presence of some cases of asymptomatic HGD/OAC in this outcome group cannot be excluded, the onset of BO apparently occurred too late to bridge the incubation period to incident HGD/OAC.
Although we aimed to choose specific and robust cutoffs for the definition of the utilized outcomes for this meta-analysis, outcome-specific bias cannot be excluded due to the combination of data from different studies in which different definitions for each outcome were used.
However, some patient groups were very small and given the lack of prospective use of validated outcome measures, it cannot be excluded that certain diagnoses have distinct response profiles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com