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Several studies with a higher level of evidence [70 74] and meta-analyses [75 77] in adults and children showed no benefit regarding mortality or neurological outcome with the use of therapeutic hypothermia between 32 and 35 °C, compared to normothermia in patients with severe TBI whether they had intracranial hypertension or not.
This is well supported by the improvements in neurological outcome with the use of hypothermia after cardiac arrest [ 10].
However, this argument assumes the ready availability of convincing, substantive evidence supporting an improved outcome with the use of the test modality.
Despite many attempts, no study has yet presented data showing improved outcome with the use of EEG monitors in ICU sedation.
The promise of improved outcome with the use of hematopoietic growth factors in the treatment of acute myelogenous leukemia (AML) has yet to be realized.
For example, our study concurs with others in showing a worse outcome with the use of older donors [ 5, 21, 22] (Tables 8 and 9).
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Studies show improved outcomes with the use of goal-directed therapy over fluid-liberal approach. .
Studies show improved outcomes with the use of goal-directed therapy over fluid-liberal approach.
However, several experimental and clinical studies report unfavourable outcomes with the use of a variety of ACM.
Others have shown similarly good clinical outcomes with the use of a locked, antegrade intramedullary nail [11, 12].
Unfortunately, clinical outcomes with the use of this approach have remained poor, with median survival times of only 8-13 months.
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