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Patient-reported outcome validation needs to achieve validity and reliability standards.
This study is strengthened by its large sample size and the inclusion of an a posteriori triage score assignment with EHR-based clinical outcome validation as comparator, yet several limitations of our findings should be considered.
The standard NOS for cohort studies contains eight questions that assess study quality based on subject selection, comparison and outcome validation.
Data collection performed without recording or a note-taking partner during the interview limits outcome validation but may augment the value of the information received.
Further, items applicable only to field studies or studies in which internal outcome validation was conducted were not useful due to the very small number of such studies.
These findings reiterate the need for adequate case retrieval in outcome validation studies and, if necessary, to perform resampling and take into account the impact of missing cases in the analysis.
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This study describes the registry design, data collection, outcomes validation, and ongoing surveillance, highlighting the unique integration with the EMR.
A consistent, bundled methodology implemented at multiple study centers would standardize processes and allow comparison of outcomes, validation of the methodology, and benchmarking.
Over the next several years, outcomes validation data will emerge to determine which of these technologies or collections of technologies will have greatest predictive value.
Measurement of tumor size is arguably a logical starting point to assess tumor response, but published criteria to date are subject to controversy and lack outcomes validation.
In addition to providing a text description of the scope of the problem, there is an extensive reference list covering topics in the field of delirium and sedation, such as risk factors, clinical outcomes, validation of assessment tools, protocols for sedation, and long-term cognitive outcomes.
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