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On Tuesday, the American Heart Association called for the Zetia outcome trial to be completed as quickly as possible.
A large outcome trial of 9vHPV vaccine was conducted.
TECOS is a pragmatic-design cardiovascular outcome trial assessing the cardiovascular effects of sitagliptin when added to usual T2DM management.
Glucose lowering medication use among patients with type 2 diabetes and advanced renal disease (eGFR < 60) in a large multinational outcome trial (TREAT) is assessed.
Studies using vitamin C were more equivocal, with 4/11 showing decreased oxidative stress and one clinical outcome trial showing no effect on morbidity or mortality.
Alpha-tocopherol was the most investigated antioxidant, with 20/25 studies reporting that this vitamin decreased oxidative stress, and one clinical outcome trial in 196 patients finding that it protected against secondary CVD.
Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor shown to reduce mortality and morbidity in the recently completed largest outcome trial in patients with HFrEF (PARADIGM-HF trial).
Fewer than 10% of conference proceedings included: identification of the trials as randomized in the title, study design as field or challenge; the primary outcome; trial status; results for primary outcome; information about harms and funding source (2/89).
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The results of the EMPA-REG-OUTCOME trial on type 2 diabetic patients at high risk for prior cardiovascular events showed that empagliflozin produces a remarkable reduction in the rates of hospitalization for heart failure (35%), cardiovascular death (38%), and all-cause death (32%).
The EMPA-REG OUTCOME™ trial is an ongoing, randomized, placebo-controlled, clinical outcomes trial powered to establish the CV safety of empagliflozin with the potential to demonstrate cardioprotection in patients with T2DM at high risk of CV events who are receiving standard of care.
This EMPA-REG OUTCOME™ trial is sponsored by BI and Eli Lilly.
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CEO of Professional Science Editing for Scientists @ prosciediting.com