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Those studies that used a reproductive outcome to select cut points and tests have the greatest clinical utility.
If appropriately designed and communicated effectively, policy- and decision-makers can use health models integrating micro- to macro-level exposures and processes that influence the occurrence of a health outcome to select a basket of policies and measures to efficiently and effectively manage health risks over shorter and longer temporal scales.
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Review authors might also be influenced by how many and which outcomes to select according to how favourable results appear to be in the published trial reports.
Importantly, in an effort to develop alternative phenotypic outcome measures to select the candidate CSC-phenotype, we were able to establish cultures in vitro with high efficiency (7/7 attempts), using the novel strategy that utilized an autologous tumor microenvironment.
Second, bivariate analyses were done for the independent variables with the outcome variable to select candidate variables for the multivariable analyses.
Martina Sester and colleagues argue that the number of individuals who need to take prophylactic medication in order to prevent one active case (number needed to treat (NNT)) would have been a better outcome measure to select at-risk populations.
By defining disease according to perturbations in cellular and molecular phenotypes and genotypes, we should be better placed to predict disease outcome and to select the most appropriate therapy for our patients.
We have demonstrated that a simple, accurate, and blood-based biomarker such as endocan/ESM-1 (EndoMark H1; Lunginnov) could assess the initial severity and closely follow the inflammatory events and endothelial dysfunction in patients, and therefore would be hugely helpful for clinicians to predict outcome and to select more appropriate therapeutic strategies.
In randomised trials researchers are required to specify analyses before seeing the outcome data, to select one of these as the primary analysis, (ideally) to make this plan public, and to adhere to the specified analyses on receipt of the outcome data.
This study demonstrates the potential benefit of using an outcomes database to select promising interventions for multicenter clinical trials and proposes novel composite endpoints for use in GVHD prevention trials.
Preclinical evaluations of mAbs to be administered by SC injection are typically performed in species such as mice, rats, minipigs, and cynomolgus monkeys to obtain critical information regarding formulation performance and prediction of PK/PD outcomes needed to select clinical doses for first-in-human studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com