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Since in vivo studies in animal models poorly correlate with clinical outcome, the need to recreate an ICC model to better understand this disease is underscored.
Since the number of categories into which a continuous predictor must be categorised depends partly on the relationship between the predictor and the outcome, the need for more than two categories must be borne in mind.
An initial randomised controlled trial of MIST had as its primary outcome the need for intubation and mechanical ventilation, and found a reduction in this outcome after MIST [ 33].
Twenty-three patients met the primary outcome, the need for renal replacement therapy (RRT) or death, of which five patients required RRT but survived, and eleven patients died but did not receive RRT. Pre-renal AKI was significantly more common among the patients who did not meet this outcome (P = 0.01).
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The number of outcomes, the need for a benefit and harm comparison metric, and the quality and quantitative of available data will likely drive the selection of approaches.
The purpose of this study was to describe patient-related outcomes, the need for additional rehabilitation after a fast-track total hip arthroplasty (THA), and the association between generic and disease specific outcomes.
While additional high-quality research studies would be beneficial for all outcomes, the need is particularly high for the majority of body structure and function outcomes, in particular BMD, cardio-respiratory, pain, skin, bowel and bladder function.
For the review's secondary outcomes, the need for misoprostol for cervical ripening was more frequent in the TVUS group compared to the Bishop score group (RR 0.52, 95% CI 0.41 to 0.66, two studies, 234 women, moderate quality evidence).
Due to both methodological advantages and the wider scope of the outcomes, the need for a large, prospective cohort study on the health of mobile phone users has been recognized in several evaluations [ 15- 17].
The primary outcome was the composite outcome of the need for RRT or death.
The outcome emphasizes the need for remote sensing based time series analyses at fine scales.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com