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We used Cox proportional hazard regression analysis to test associations between the outcome (severe hypoglycemia episodes) and potential explanatory variables.
Clinical trials targeting EGFR or COX-2 failed to improve the treatment outcome; severe side effects were even noted.
The predictive outcome – severe hyperbilirubinemia – was defined differently in the presented studies of different strategies for risk assessment.
No significant difference was found between groups for poor clinical outcome (severe disability or death), which was the primary endpoint of the study.
Lesions >10 mm on diffusion-weighted imaging scans performed within 24 hours of haemorrhage were predictive of poor outcome (severe disability, vegetative state or death).
A retrospective sensitivity analysis was carried out on the outcome severe hyperkalaemia, stratifying patients by their risk of hyperkalaemia into low and high risk groups (fig 5).
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Clinical data are extracted for relevant patient outcomes, severe sepsis, and indicators of critical illness.
Substantive outcomes: severe malaria, which includes severe anaemia (defined as Hb < 8 g/dL, < 7 g/dL, < 6 g/dL); severe adverse events.
The 32 graft donors were matched with recipients of the following transplant outcomes: severe aGVHD (n = 9), mild aGVHD (n = 8), and no aGVHD (n = 15).
We also used these stratified analyses to look for interactions between these covariables and brachial artery reactivity in predicting the primary outcomes (severe sepsis and hospital mortality) [ 42].
In brief, at the individual level, these variables include maternal and newborn individual data, data related to the pregnancy outcomes, severe complications and their management.
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