Although advantageous aspects of volume replacement with so-called "modern" isooncotic tetrastarch solutions, in particular in reaching early hemodynamic stability are comprehensible [31, 32], data on focussed, adequately powered, prospective clinical trials proving their outcome-relevance are needed.
Although advantageous aspects of volume replacement with so-called "modern" isooncotic tetrastarch solutions, in particular in reaching early hemodynamic stability are comprehensible [ 31, 32], data on focussed, adequately powered, prospective clinical trials proving their outcome-relevance are needed.
We believe that the overall, systematic picture of perceived outcome has relevance in itself.
In this first round, indicators were rated on only four attributes: link to outcome, reliability, relevance and actionability.
While acceleration of gastric emptying may not improve fasting, or mealrelated, symptoms in ambulatory patients with gastroparesis, acceleration of the gastric emptying rate and, thereby, improving enteral feed tolerance is the primary outcome of relevance in the sedated critically ill patient, rather than symptom relief [ 6].
Current findings need to be viewed from a critical perspective and research designs in the future have to be adjusted and refined in order to provide consistent and satisfactory outcomes with relevance for real-life outcomes.
The most important limitation of this review is that markers of airway inflammation are surrogate outcomes rather than practice-changing outcomes of relevance to clinicians; however, the results of this review do add to our understanding of the effects of exercise on asthmatic airways.
Fourth, although we assessed a relatively broad range of outcomes of relevance to high quality care, some salient measures such as disease-specific outcomes, were not assessed.
It has the limitation, however, that although we are collecting data to enable investigation of other morbidity and mortality outcomes, the relevance of the exposure data available will diminish the more that the aetiology of the outcome is unlike that for breast cancer.
Clinical trials are most informative for evidence-based decision making when they consistently measure and report outcomes of relevance to stakeholders.
Child mental health treatment and services research yields more immediate public health benefit when they focus on outcomes of relevance to a broader group of stakeholders.
