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Our study adds to the limited knowledge on specific comorbidity asthma outcome relations throughout adult life.
In the crude analysis, incidence rate ratios (IRRs) of the relations between exposure and outcome relations were estimated.
Curves for other end points did not suggest specific time windows for exposure outcome relations [see Supplemental Material, Figure 3A 3D (http://dx.doi.org/10.1289/ehp.1103934)].
25(OH D-health OH D-healthatioutcomenge relationsor 25(OH)D changetrapidly below 50 nmol/L, then change slowly for higher values.
Although previous reports and biological plausibility consistently suggest that lipid levels would be associated with the serum uric acid levels as observed, a cross-sectional study design tends to leave uncertainty regarding the temporal sequence of exposure, outcome relations.
We formulated initial key questions on the basis of a generic analytic framework for assessments of nutrient and outcome relations(24).
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While it is well accepted that this introduces bias and imprecision in exposure-outcome relations, it is unclear to what extent such issues are currently considered in research practice.
We applied multivariate methods for assessing the exposure-outcome relations.
But aggregation may simultaneously weaken covariate-exposure and/or covariate-outcome relations, reducing prioritization in the Bross formula [ 19].
► We tested whether these aspects of agency are differentially affected by sequential patterns of action-outcome relations.
The latter implies that the average level of a given group affects the individuals' within-group relation (e.g. the effect of neighbourhoods on individual-level exposure-outcome relations).
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