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The 18% is similar to the 7 17% reduction achieved by increasing serum 25(OH D concentration from 54 to 110 nmol/l, as estimated in a recent study based on the serum 25(OH D concentration disease outcome relation for diseases contributing the most to all-cause mortality rate: cancer, cardiovascular disease, diabetes mellitus, respiratory diseases, respiratory infections, and tuberculosis.
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Our study adds to the limited knowledge on specific comorbidity asthma outcome relations throughout adult life.
In the crude analysis, incidence rate ratios (IRRs) of the relations between exposure and outcome relations were estimated.
Curves for other end points did not suggest specific time windows for exposure outcome relations [see Supplemental Material, Figure 3A 3D (http://dx.doi.org/10.1289/ehp.1103934)].
25(OH D-health OH D-healthatioutcomenge relationsor 25(OH)D changetrapidly below 50 nmol/L, then change slowly for higher values.
Third, it simplifies the analysis of changes in the exposure-outcome relation.
One study investigated the volume-outcome relation in medical ICU patients [ 26].
Several reasons might explain the lack of a volume-outcome relation in this study.
To be more precise, the approach proposed by Lange et al. [ 17] requires that the considered variables are sufficient for controlling the confounding of 1) the exposure-outcome relation, 2) the exposure-mediator relation, and 3) the mediator-outcome relation.
22 23 24 Two of these studies showed a volume-outcome relation, but the third study failed to do so.
This will also need to be combined with research exploring the volume-outcome relation for outcomes other than mortality.
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