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Environ Health Perspect 124:53–60; http://dx.doi.org/10.1289/ehp.1409450 The adverse outcome pathway (AOP) is a conceptual framework originally developed with the goal of utilizing pathways-based data to support ecotoxicology research and risk assessment (Ankley et al. 2010).
Applying toxicity and adverse outcome pathway analyses to synthetic biology is also discussed.
A retinoic acid neural tube/axial patterning adverse outcome pathway (RA NTA AOP) framework was designed.
Four sections comprise assay results corresponding to the four key events of adverse outcome pathway for skin sensitization.
Recently, skin sensitization has been formulated as an adverse outcome pathway (AOP) to address the complex nature of sensitization [19].
This study demonstrated how information can be obtained using adverse outcome pathway framework to derive biological effect-based monitoring tools.
Similar(17)
adverse outcome pathways.
This could be extended towards representing mixture adverse outcome pathways.
These include mode of action and adverse outcome pathways.
Adverse outcome pathways (AOPs) are novel tools in toxicology and human risk assessment with broad potential.
High-throughput toxicology has defined adverse outcome pathways (AOPs), prioritized chemicals of concern, and identified novel actions of environmental chemicals.
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