Neo-Darwinian theory, and the bet-hedging model in particular, offers a way to evaluate both kinds of agronomic change within a single theoretical paradigm, as well as a means of assessing the long-term outcomes of variant agronomic strategies.
In fact, two previous studies did not demonstrate that renal outcome of tip variant is better than that of NOS variant [ 10, 14].
In one meta-analysis that included only patients with acute coronary syndromes, there was strong evidence for an effect of variant alleles on outcomes, whereas another analysis that included trials with different indications (and in which the efficacy of clopidogrel itself appears to be less) reported a much smaller effect of genetic variation on outcome.
Larger cohorts will also help to identify common variants which could influence the outcome of other variants such as CNVs.
We checked the effect of the NMD inhibitor cycloheximide on the splicing outcome of four variants (c.8486A>T, c.8754+4A>G, c.8948_8953+5del, and c.9649-2A>G).
Therefore, the correct strategy will probably be to confirm experimentally only the mostly frequently discovered mutations and to build a predictive model to estimate the outcome of rarer variants based on knowledge about the genetic context.
The GIC's application of its "developmental model" is divorced from important community resources and inconsistent with longitudinal follow-up data on outcomes of gender variant children.
The characterizations in Table 1 specify the nature of the resource constraints, the demographic constraints, and the outcome of competition between variant and incumbent for the resources.
They suggest that the outcome of a repair variant in a cell may depend on the selection pressures exerted on that cell.
First, the patient sample might not be available and, second, leukocytes are the main source of RNA, so caution should be taken when interpreting these results since differential tissue-specific alternative splicing events could mask the real splicing outcome of a DNA variant [ 21, 34].
