Sentence examples for outcome of targeted from inspiring English sources
This chapter will discuss the following areas that can affect the outcome of targeted drug delivery: the enhanced permeability and retention (EPR) effect, tumor microenvironment, intratumoral distribution, tumor heterogeneity, and multidrug resistance.
The predicted TCPs are of theoretical nature and need to be compared with the outcome of targeted radionuclide experiments.
We recently assessed the performance and outcome of targeted next-generation sequencing with archived endoscopic ultrasound fine-needle aspirates across a broad range of primary and metastatic sites with encouraging accuracy.
When we examined the outcome of targeted ablations at E12.5, we found that each mutant exhibited a mild facial phenotype (Fig. 7A D).
Functional support for the participation of BRCA1 in the DNA damage response is presented by studying the phenotypic outcome of targeted Brca1 deletions.
One uses 'targeting-induced local lesions in genomes' (TILLING), a process by which random mutagenesis and individual exon sequencing are carried out to identify mutations within a particular gene, essentially mimicking the outcome of targeted mutagenesis [ 24].
This variability makes it difficult to predict the likely outcome of targeting group III mGlu receptors in the SNr in the early stages of PD.
Here, we focus on the differential regulation of PXR in a tissue-specific manner and how the tissue-specificity of expression/function may affect the overall outcome of targeting PXR in human disease.
With the disappointing outcomes of targeting individual Th-2 cytokines or manipulating T-cells, the time has come to re-evaluate the direction of research in this disease.
Feedback loops are important regulators of signaling pathway [ 90] and might be involved in unexpected and undesirable outcomes of targeting therapies.
This is particularly relevant in face of the lacking positive or even negative results of previous large studies on the outcome effects of targeting supra-normal oxygen delivery in critically ill patients [ 24, 25].
