Sentence examples for outcome of target from inspiring English sources

Structure-property relationships, central to many of today's drug discovery strategies, are not straightforward to deal with when trying to predict drug efficacy, that is, the combined outcome of target affinity, pharmacodynamic behavior, pharmacokinetic properties, and metabolic fate.

This high number of predicted target genes seems incompatible with the very specific phenotypic defects observed in the miR-10 overexpression embryos and strongly suggest that, at least for miR-10, there is a high component of false positives in the outcome of target prediction algorithms.

PDZ selectivity, which we for simplicity define here as the final and reproducible outcome of target binding in the cell in the presence of other potential ligands, may thus still be relatively weak on the genomic level, particularly given the already extensive protein-domain promiscuity and the micromolar specificity of the domains described to date.

Dependent variables indicated outcome of target population's use of health services.

For the outcome of target lesion revascularisation the results were largely similar, except that the results of the comparison between bare metal stents and zotarolimus eluting stent was no longer significant (trend favouring zotarolimus eluting stent) and sirolimus eluting stents were significantly more efficacious than paclitaxel eluting stents (fig 3 and fig A2 in appendix 2).

Another study performed by Berenguer et al. showed higher restenosis rates for insulin-treated DM patients after sirolimus-eluting stenting as well as a non-statistically significant difference for the clinical outcome of target vessel failure (death, MI, or TVR, 17.4 vs 7.7%%, p < 0.07) [ 25].

This chapter will discuss the following areas that can affect the outcome of targeted drug delivery: the enhanced permeability and retention (EPR) effect, tumor microenvironment, intratumoral distribution, tumor heterogeneity, and multidrug resistance.

This variability makes it difficult to predict the likely outcome of targeting group III mGlu receptors in the SNr in the early stages of PD.

Here, we focus on the differential regulation of PXR in a tissue-specific manner and how the tissue-specificity of expression/function may affect the overall outcome of targeting PXR in human disease.

Because of the frequent feedback loops occurring in complex systems, it is difficult that a single intervention could be sufficient to significantly influence the long-term outcome of the target objective.

With the disappointing outcomes of targeting individual Th-2 cytokines or manipulating T-cells, the time has come to re-evaluate the direction of research in this disease.