The outcome of our screen, together with past aneugenic evidence, predicts a potential reproductive hazard of thiabendazole.
Because it is not yet feasible to test in the mouse all genes supported as modifiers of neuronal decline in simple models, the outcome of our functional screen and other screens will be analyzed using data integration procedures in which the selection of the best targets for validation will rely on target expression levels and activity in multiple models of HD.
Three-way alignments of the three crocodilians were compiled for all these loci in order not to bias the outcome of our experimental screening toward one of the two competing hypothesis regarding the position of the gharial.
Comparison of the results of our screen with the outcome of two recently published bioinformatics tools showed a low level of overlap between putative sRNA genes.
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In this study, we considered high-grade ESD as the outcome of interest in our screening programme, because it is the clinically most important precursor lesion of ESCC and the point in the spectrum of ESD at which therapeutic intervention would be recommended.
Uptake and outcome of screening are presented by screening rounds, with results combined for later screening rounds as yet incomplete.
Information from screening (initial or successive screening, date of screening mammogram, further assessments, the use of SFM or FFDM, and the final outcome of screening) was obtained from the screening program database.
That said, randomized control trials indicating objective benefit of treatment outcomes of screening vs. no screening strategies are lacking.
The study results emphasise the need for standardised data to be recorded nationally on the outcome of screening so that the effects of screening can be studied.
